There’s a rather interesting interview with Samantha Who? executive producer Donald Todd over at The Futon Critic. He addresses the now shortened season issue and what the future of the remaining episodes is, as well as character matters such the future of Regina.
The full interview can be found: Here.

For selected answers of relevance to here: JH: Belated congratulations on Jean Smart’s Emmy win last fall. What’s coming up for Regina?

DT: Thank you. Jean is great and we always are trying to find things to do with her. And there’s a situation where we have a solid marriage in the show but a character who has always wanted to explore more outside of her life than she’s been able to do in her marriage and Samantha continues to be a catalyst for her self-discovery. So what will happen in the next few weeks is that she becomes increasingly restless with the life that she has especially when reflected in the exciting life that she sees Sam having.

JH: Assuming the episodes do well in the ratings, any chance they’ll try to find a spot for the remaining episodes this season?

DT: Right now, they say they have no spots because “Ugly Betty” is coming back into that spot and they’ve given us a good run in a really good time slot but they also have a lot of “Ugly Betty” episodes to run. I think that a network finds itself airing extra reality shows than they meant to and then they end up with the scripted shows in a pile on the floor and that’s the kind of situation they’re in right now. Look, I would love it if we could air more episodes but it would mean that someone else’s show failed and I don’t want to wish that karmically or otherwise. We have eleven and the one airing [this week] was meant to be a January airing and you plan your season a certain way where you’ve got peaks and valleys that flow and all of a sudden we had to pick six episodes that would represent out entire back half of the season so I hope we do well.